Evolving from single-celled yellow organisms at the dawn of time, Minions live to serve, but find themselves working for a continual series of unsuccessful masters, from T. Rex to Napoleon. Without a master to grovel for, the Minions fall into a deep depression. But one minion, Kevin, has a plan; accompanied by his pals Stuart and Bob, Kevin sets forth to find a new evil boss for his brethren to follow. Their search leads them to Scarlet Overkill, the world's first-ever super-villainess.

When monsters want to get away from it all, they go to Count Dracula's (Adam Sandler) Hotel Transylvania, a lavish resort where they can be themselves without humans around to bother them. On one special weekend, Dracula invites creatures like the Invisible Man, the Mummy and others to celebrate the 118th birthday of his daughter, Mavis (Selena Gomez). However, an unforeseen complication unfolds when an ordinary human unwittingly crashes the party and falls in love with Mavis.